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Publications

2024

  • Xu M, Ito-Kureha T, Kang HS, Chernev A, Raj T, Hoefig KP, Hohn C, Giesert F, Wang Y, Pan W, Ziętara N, Straub T, Feederle R, Daniel C, Adler B, König J, Feske S, Tsokos GC, Wurst W, Urlaub H, Sattler M, Kisielow J, Wulczyn FG, Łyszkiewicz M, Heissmeyer V. The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression. Nat Commun. 2024 Mar 11;15(1):2194. doi: 10.1038/s41467-024-46371-z
  • Zhou Q, Pichlmeier S, Denz AM, Schreiner N, Straub T, Benitz S, Wolff J, Fahr L, Del Socorro Escobar Lopez M, Kleeff J, Mayerle J, Mahajan UM, Regel I. Altered histone acetylation patterns in pancreatic cancer cell lines induce
    subtype‑specific transcriptomic and phenotypical changes. Int J Oncol. 2024 Mar;64(3):26. doi: 10.3892/ijo.2024.5614.
  • Popper B, Bürkle M, Ciccopiedi G, Marchioretto M, Forné I, Imhof A, Straub T, Viero G, Götz M, Schieweck R. Ribosome inactivation regulates translation elongation in neurons. J Biol Chem. 2024 Jan 12:105648. doi: 10.1016/j.jbc.2024.105648

2023

  • Chanou A, Weiβ M, Holler K, Sajid A, Straub T, Krietsch J, Sanchi A, Ummethum H, Lee CSK, Kruse E, Trauner M, Werner M, Lalonde M, Lopes M, Scialdone A, Hamperl S. Single molecule MATAC-seq reveals key determinants of DNA replication origin efficiency. Nucleic Acids Res. 2023 Nov 13:gkad1022. doi: 10.1093/nar/gkad1022.
  • Mahnic N, Geremia A, Straub T, Zorzato S, Schönfelder M, von Lüttichau I, Steiger K, Saller MM, Blaauw B, Wackerhage H. One bout of endurance exercise does not change gene expression or proliferation in a C26 colon carcinoma in immunocompetent mice. J Cancer Res Clin Oncol. 2023 Oct 16. doi:
    10.1007/s00432-023-05447-x.
  • Angerilli A, Tait J, Berges J, Shcherbakova I, Pokrovsky D, Schauer T, Smialowski P, Hsam O, Mentele E, Nicetto D, Rupp RA. The histone H4K20 methyltransferase SUV4-20H1/KMT5B is required for multiciliated cell differentiation in Xenopus. Life Sci Alliance. 2023 Apr 28;6(7):e202302023. doi:
    10.26508/lsa.202302023.
  • Nixdorf D, Sponheimer M, Berghammer D, Engert F, Bader U, Philipp N, Kazerani M, Straub T, Rohrbacher L, Wange L, Dapa S, Atar D, Seitz CM, Brandstetter K, Linder A, von Bergwelt M, Leonhardt H, Mittelstaet J, Kaiser A, Bücklein V, Subklewe M. Adapter CAR T cells to counteract T-cell exhaustion and enable flexible targeting in AML. Leukemia. 2023 Apr 27. doi: 10.1038/s41375-023-01905-0.
  • Rausch L, Flaskamp L, Ashokkumar A, Trefzer A, Ried C, Buchholz VR, Obst R, Straub T, Brocker T, Kranich J. Phosphatidylserine-positive extracellular vesicles boost effector CD8<sup>+</sup> T cell responses during viral infection. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2210047120. doi: 10.1073/pnas.2210047120.
  • Chacin E, Reusswig KU, Furtmeier J, Bansal P, Karl LA, Pfander B, Straub T, Korber P, Kurat CF. Establishment and function of chromatin organization at replication origins. Nature. 2023 Apr 5. doi: 10.1038/s41586-023-05926-8.
  • Rohwedder I, Wackerbarth LM, Heinig K, Ballweg A, Altstätter J, Ripphahn M, Nussbaum C, Salvermoser M, Bierschenk S, Straub T, Gunzer M, Schmidt-Supprian M, Kolben T, Schulz C, Ma A, Walzog B, Heinig M, Sperandio M. A20 and the noncanonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogeny. JCI Insight. 2023 Feb 22;8(4):e155968. doi: 10.1172/jci.insight.155968.
  • Oberbeckmann E, Wolff MR, Krietenstein N, Heron M, Schmid A, Straub T, Gerland U, Korber P. ORE-Seq: Genome-Wide Absolute Occupancy Measurement by Restriction Enzyme Accessibilities. Methods Mol Biol. 2023;2611:121-152. doi: 10.1007/978-1-0716-2899-7_9.
  • Ho S, Oswald E, Wong HK, Vural A, Yilmaz V, Tüzün E, Türkoğlu R, Straub T, Meinl I, Thaler F, Kümpfel T, Meinl E, Mader S. Ocrelizumab Treatment Modulates B-Cell Regulating Factors in Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2023 Jan 26;10(2):e200083.doi: 10.1212/NXI.0000000000200083.
  • Rohwedder I, Wackerbarth LM, Heinig K, Ballweg A, Altstätter J, Ripphahn M, Nussbaum C, Salvermoser M, Bierschenk S, Straub T, Gunzer M, Schmidt-Supprian M, Kolben T, Schulz C, Ma A, Walzog B, Heinig M, Sperandio M. A20 and the non-canonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogeny. JCI Insight. 2023 Jan 12:e155968. doi: 10.1172/jci.insight.155968

2022

  • Sun B, Smialowski P, Aftab W, Schmidt A, Forne I, Straub T, Imhof A. Improving SWATH-MS analysis by deep-learning. Proteomics. 2022 Dec 26:e2200179. doi: 10.1002/pmic.202200179
  • Abe K, Schauer T, Torres-Padilla ME. Distinct patterns of RNA polymerase II and transcriptional elongation characterize mammalian genome activation. Cell Rep. 2022 Dec 27;41(13):111865. doi: 10.1016/j.celrep.2022.111865.
  • Papadopoulou AA, Stelzer W, Silber M, Schlosser C, Spitz C, Haug-Kröper M, Straub T, Müller SA, Lichtenthaler SF, Muhle-Goll C, Langosch D, Fluhrer R. Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage. Sci Rep. 2022 Dec 5;12(1):20987. doi: 10.1038/s41598-022-24772-8.
  • Sicilia C, Corral-Lugo A, Smialowski P, McConnell MJ, Martín-Galiano AJ. Unsupervised Machine Learning Organization of the Functional Dark Proteome of Gram-Negative "Superbugs": Six Protein Clusters Amenable for Distinct Scientific Applications. ACS Omega. 2022 Dec 6;7(50):46131-46145. doi:10.1021/acsomega.2c04076
  • Brech D, Herbstritt AS, Diederich S, Straub T, Kokolakis E, Irmler M, Beckers J, Büttner FA, Schaeffeler E, Winter S, Schwab M, Nelson PJ, Noessner E. Dendritic Cells or Macrophages? The Microenvironment of Human Clear Cell Renal Cell Carcinoma Imprints a Mosaic Myeloid Subtype Associated with Patient Survival. Cells. 2022 Oct 19;11(20):3289. doi: 10.3390/cells11203289.
  • Philipp N, Kazerani M, Nicholls A, Vick B, Wulf J, Straub T, Scheurer M, Muth A, Hänel G, Nixdorf D, Sponheimer M, Ohlmeyer M, Lacher SM, Brauchle B, Marcinek A, Rohrbacher L, Leutbecher A, Rejeski K, Weigert O, von Bergwelt-Baildon M, Theurich S, Kischel R, Jeremias I, Bücklein V, Subklewe M. T-cell exhaustion induced by continuous bispecific molecule exposure is ameliorated by treatment- free intervals. Blood. 2022 Sep 8;140(10):1104 1118. doi: 10.1182/blood.2022015956
  • Zauhar R, Biber J, Jabri Y, Kim M, Hu J, Kaplan L, Pfaller AM, Schäfer N, Enzmann V, Schlötzer-Schrehardt U, Straub T, Hauck SM, Gamlin PD, McFerrin MB, Messinger J, Strang CE, Curcio CA, Dana N, Pauly D, Grosche A, Li M, Stambolian D. As in Real Estate, Location Matters: Cellular Expression of Complement Varies Between Macular and Peripheral Regions of the Retina and Supporting Tissues. Front Immunol. 2022 Jun 15;13:895519. doi: 10.3389/fimmu.2022.895519
  • O'Neill AC, Uzbas F, Antognolli G, Merino F, Draganova K, Jäck A, Zhang S, Pedini G, Schessner JP, Cramer K, Schepers A, Metzger F, Esgleas M, Smialowski P, Guerrini R, Falk S, Feederle R, Freytag S, Wang Z, Bahlo M, Jungmann R, Bagni C, Borner GHH, Robertson SP, Hauck SM, Götz M. Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity. Science. 2022 Jun 17;376(6599):eabf9088. doi: 10.1126/science.abf9088.
  • Zieger N, Kazerani M, Nicholls A, Vick B, Wulf J, Straub T, Scheurer M, Muth A, Hänel G, Nixdorf D, Sponheimer M, Ohlmeyer M, Lacher SM, Brauchle B, Marcinek A, Rohrbacher L, Leutbecher A, Rejeski K, Weigert O, von Bergwelt-Baildon M, Theurich S, Kischel R, Jeremias I, Bücklein VL, Subklewe M. T-cell exhaustion induced by continuous bispecific molecule exposure is ameliorated by treatment-free intervals. Blood. 2022 Jul 25:blood.2022015956. doi: 10.1182/blood.2022015956.
  • Sanchez-Gonzalez R, Koupourtidou C, Lepko T, Zambusi A, Novoselc KT, Durovic T, Aschenbroich S, Schwarz V, Breunig CT, Straka H, Huttner HB, Irmler M, Beckers J, Wurst W, Zwergal A, Schauer T, Straub T, Czopka T, Trümbach D, Götz M, Stricker SH, Ninkovic J. Innate Immune Pathways Promote Oligodendrocyte Progenitor Cell Recruitment to the Injury Site in Adult Zebrafish Brain. Cells. 2022 Feb 2;11(3):520. doi: 10.3390/cells11030520

2021

  • Elhag S, Stremmel C, Zehrer A, Plocke J, Hennel R, Keuper M, Knabe C, Winterhalter J, Gölling V, Tomas L, Weinberger T, Fischer M, Liu L, Wagner F, Lorenz M, Stark K, Häcker H, Schmidt-Supprian M, Völker U, Jastroch M, Lauber K, Straub T, Walzog B, Hammer E, Schulz C. Differences in Cell-Intrinsic Inflammatory Programs of Yolk Sac and Bone Marrow Macrophages. Cells. 2021 Dec 17;10(12):3564. doi: 10.3390/cells10123564.
  • Weckbach LT, Schweizer L, Kraechan A, Bieber S, Ishikawa-Ankerhold H, Hausleiter J, Massberg S, Straub T, Klingel K, Grabmaier U, Zwiebel M, Mann M, Schulz C; EMB Study Group. Association of Complement and MAPK Activation With SARS-CoV-2-Associated Myocardial Inflammation. JAMA Cardiol. 2021 Dec 15. doi: 10.1001/jamacardio.2021.5133.
  • Ohlig S, Clavreul S, Thorwirth M, Simon-Ebert T, Bocchi R, Ulbricht S, Kannayian N, Rossner M, Sirko S, Smialowski P, Fischer-Sternjak J, Götz M. Molecular diversity of diencephalic astrocytes reveals adult astrogenesis
    regulated by Smad4. EMBO J. 2021 Nov 2;40(21):e107532. doi: 10.15252/embj.2020107532
  • Rausch L, Lutz K, Schifferer M, Winheim E, Gruber R, Oesterhaus EF, Rinke L, Hellmuth JC, Scherer C, Muenchhoff M, Mandel C, Bergwelt-Baildon M, Simons M, Straub T, Krug AB, Kranich J, Brocker T. Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients. J Extracell Vesicles. 2021 Dec;10(14):e12173. doi: 10.1002/jev2.12173
  • Singh AK, Schauer T, Pfaller L, Straub T, Mueller-Planitz F. The biogenesis and function of nucleosome arrays. Nat Commun. 2021 Dec 1;12(1):7011. doi: 10.1038/s41467-021-27285-6.
  • Murawska M, Greenstein RA, Schauer T, Olsen KCF, Ng H, Ladurner AG, Al-Sady B, Braun S. The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states. Cell Rep. 2021 Nov 2;37(5):109944. doi: 10.1016/j.celrep.2021.109944
  • Winheim E, Rinke L, Lutz K, Reischer A, Leutbecher A, Wolfram L, Rausch L, Kranich J, Wratil PR, Huber JE, Baumjohann D, Rothenfusser S, Schubert B, Hilgendorff A, Hellmuth JC, Scherer C, Muenchhoff M, von Bergwelt-Baildon M, Stark K, Straub T, Brocker T, Keppler OT, Subklewe M, Krug AB. Impaired function and delayed regeneration of dendritic cells in COVID-19. PLoS Pathog. 2021 Oct 6;17(10):e1009742. doi: 10.1371/journal.ppat.1009742
  • Pokrovsky D, Forné I, Straub T, Imhof A, Rupp RAW. A systemic cell cycle block impacts stage-specific histone modification profiles during Xenopus embryogenesis. PLoS Biol. 2021 Sep 7;19(9):e3001377. doi: 10.1371/journal.pbio.3001377
  • Lukacs A, Thomae AW, Krueger P, Schauer T, Venkatasubramani AV, Kochanova NY, Aftab W, Choudhury R, Forne I, Imhof A. The Integrity of the HMR complex is necessary for centromeric binding and reproductive isolation in Drosophila. PLoS Genet. 2021 Aug 23;17(8):e1009744. doi: 10.1371/journal.pgen.1009744
  • Kempf J, Knelles K, Hersbach BA, Petrik D, Riedemann T, Bednarova V, Janjic A, Simon-Ebert T, Enard W, Smialowski P, Götz M, Masserdotti G. Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2. Cell Rep. 2021 Jul 20;36(3):109409. doi:10.1016/j.celrep.2021.109409.
  • Villa R, Jagtap PKA, Thomae AW, Campos Sparr A, Forné I, Hennig J, Straub T, Becker PB. Divergent evolution toward sex chromosome-specific gene regulation in Drosophila. Genes Dev. 2021 Jun 17. doi:10.1101/gad.348411.121.
  • Sun B, Smialowski P, Straub T, Imhof A. Investigation and Highly Accurate Prediction of Missed Tryptic Cleavages by Deep Learning. J Proteome Res. 2021 Jun 17. doi:10.1021/acs.jproteome.1c00346
  • Oberbeckmann E, Krietenstein N, Niebauer V, Wang Y, Schall K, Moldt M, Straub T, Rohs R, Hopfner KP, Korber P, Eustermann S. Genome information processing by the INO80 chromatin remodeler positions nucleosomes. Nat Commun. 2021 May 28;12(1):3231. doi:10.1038/s41467-021-23016-z.
  • Müller M, Schauer T, Becker PB. Identification of Intrinsic RNA Binding Specificity of Purified Proteins by in vitro RNA Immunoprecipitation (vitRIP). Bio Protoc. 2021 Mar 5;11(5):e3946. doi:10.21769/BioProtoc.3946
  • Buschle A, Mrozek-Gorska P, Cernilogar FM, Ettinger A, Pich D, Krebs S, Mocanu B, Blum H, Schotta G, Straub T, Hammerschmidt W. Epstein-Barr virus inactivates the transcriptome and disrupts the chromatin architecture of its
    host cell in the first phase of lytic reactivation. Nucleic Acids Res. 2021 Mar 1:gkab099. doi:10.1093/nar/gkab099.
  • Peritore M, Reusswig KU, Bantele SCS, Straub T, Pfander B. Strand-specific ChIP-seq at DNA breaks distinguishes ssDNA versus dsDNA binding and refutes single-stranded nucleosomes. Mol Cell. 2021 Feb 18:S1097 2765(21)00091-5. doi:10.1016/j.molcel.2021.02.005
  • Trefzer A, Kadam P, Wang SH, Pennavaria S, Lober B, Akçabozan B, Kranich J, Brocker T, Nakano N, Irmler M, Beckers J, Straub T, Obst R. Dynamic adoption of anergy by antigen-exhausted CD4+ T cells. Cell Rep. 2021 Feb 9;34(6):108748. doi: 10.1016/j.celrep.2021.108748.
  • Friedrich V, Forné I, Matzek D, Ring D, Popper B, Jochum L, Spriewald S, Straub T, Imhof A, Krug A, Stecher B, Brocker T. Helicobacter hepaticus is required for immune targeting of bacterial heat shock protein 60 and fatal colitis in mice. Gut Microbes. 2021 Jan-Dec;13(1):1-20. doi: 10.1080/19490976.2021.1882928.
  • Papaioannou NE, Salei N, Rambichler S, Ravi K, Popovic J, Küntzel V, Lehmann CHK, Fiancette R, Salvermoser J, Gajdasik DW, Mettler R, Messerer D, Carrelha J, Ohnmacht C, Haller D, Stumm R, Straub T, Jacobsen SEW, Schulz C, Withers DR, Schotta G, Dudziak D, Schraml BU. Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice. Nat Commun. 2021 Jan 19;12(1):464. doi:10.1038/s41467-020-20659-2.

2020

  • Juhász S, Smith R, Schauer T, Spekhardt D, Mamar H, Zentout S, Chapuis C, Huet S, Timinszky G. The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment. Sci Adv. 2020 Dec 18;6(51):eabb8626. doi:
    10.1126/sciadv.abb8626. PMID: 33355125.
  • Lange Canhos L, Chen M, Falk S, Popper B, Straub T, Götz M, Sirko S. Repetitive injury and absence of monocytes promote astrocyte self-renewal and neurological recovery. Glia. 2020 Aug 3. doi: 10.1002/glia.23893
  • Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RT, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, Dichgans M. Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability. Circ Res. 2020 Jun 17. doi:10.1161/CIRCRESAHA.120.316743
  • Müller M, Schauer T, Krause S, Villa R, Thomae AW, Becker PB. Two-step mechanism for selective incorporation of lncRNA into a chromatin modifier. Nucleic Acids Res. 2020 Jun 8:gkaa492. doi: 10.1093/nar/gkaa492.
  • Scacchetti A, Schauer T, Reim A, Apostolou Z, Campos Sparr A, Krause S, Heun P, Wierer M, Becker PB.
    Drosophila SWR1 and NuA4 complexes are defined by DOMINO isoforms. Elife. 2020 May 20;9:e56325. doi: 10.7554/eLife.56325.
  • Kochanova NY, Schauer T, Mathias GP, Lukacs A, Schmidt A, Flatley A, Schepers A, Thomae AW, Imhof A. A multi-layered structure of the interphase chromocenter revealed by proximity-based biotinylation. Nucleic Acids Res. 2020 May 7;48(8):4161-4178. doi: 10.1093/nar/gkaa145
  • Taha S, Volkmer E, Haas E, Alberton P, Straub T, David-Rus D, Aszodi A, Giunta R, Saller MM. Differences in the Inflammatory Response of White Adipose Tissue and Adipose-Derived Stem Cells. Int J Mol Sci. 2020 Feb 6;21(3):E1086. doi: 10.3390/ijms21031086.
  • Brech D, Straub T, Kokolakis E, Irmler M, Beckers J, Buettner F, Schaeffeler E, Winter S, Schwab M, Nelson PJ, Noessner E. A mosaic renal myeloid subtype with T-cell inhibitory and protumoral features is linked to immune escape and survival in clear cell renal cell cancer. bioRxiv. doi: 10.1101/2020.01.20.912865
  • Salei N, Rambichler S, Salvermoser J, Papaioannou NE, Schuchert R, Pakalniškytė D, Li N, Marschner JA, Lichtnekert J, Stremmel C, Cernilogar FM, Salvermoser M, Walzog B, Straub T, Schotta G, Anders HJ, Schulz C, Schraml BU. The Kidney Contains Ontogenetically Distinct Dendritic Cell and Macrophage Subtypes throughout Development That Differ in Their Inflammatory Properties. J Am Soc Nephrol. 2020 Jan 13. pii: ASN.2019040419. doi: 10.1681/ASN.2019040419.

2019

  • Murawska M, Schauer T, Matsuda A, Wilson MD, Pysik T, Wojcik F, Muir TW, Hiraoka Y, Straub T, Ladurner AG. The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions. Mol Cell. 2019 Dec 3. pii: S1097-2765(19)30864-0. doi: 10.1016/j.molcel.2019.11.016
  • Pauly D, Agarwal D, Dana N, Schäfer N, Biber J, Wunderlich KA, Jabri Y, Straub T, Zhang NR, Gautam AK, Weber BHF, Hauck SM, Kim M, Curcio CA, Stambolian D, Li M, Grosche A. Cell-Type-Specific Complement Expression in the Healthy and Diseased Retina. Cell Rep. 2019 Nov 26;29(9):2835-2848.e4. doi: 10.1016/j.celrep.2019.10.084.
  • Albig C, Wang C, Dann GP, Wojcik F, Schauer T, Krause S, Maenner S, Cai W, Li Y, Girton J, Muir TW, Johansen J, Johansen KM, Becker PB, Regnard C. JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila. Nat Commun. 2019 Nov 25;10(1):5343. doi: 10.1038/s41467-019-13174-6.
  • Cernilogar FM, Hasenöder S, Wang Z, Scheibner K, Burtscher I, Sterr M, Smialowski P, Groh S, Evenroed IM, Gilfillan GD, Lickert H, Schotta G. Pre-marked chromatin and transcription factor co-binding shape the pioneering activity of Foxa2. Nucleic Acids Res. 2019 Jul 27.doi: 10.1093/nar/gkz627
  • Prayitno K, Schauer T, Regnard C, Becker PB. Progressive dosage compensation during Drosophila embryogenesis is reflected by gene arrangement. EMBO Rep. 2019 Jul 9:e48138. doi: 10.15252/embr.201948138
  • Harpprecht L, Baldi S, Schauer T, Schmidt A, Bange T, Robles MS, Kremmer E, Imhof A, Becker PB. A Drosophila cell-free system that senses DNA breaks and triggers phosphorylation signalling. Nucleic Acids Res. 2019 May 31. pii: gkz473. doi: 10.1093/nar/gkz473
  • Borsos M, Perricone SM, Schauer T, Pontabry J, de Luca KL, de Vries SS, Ruiz-Morales ER, Torres-Padilla ME, Kind J. Genome-lamina interactions are established de novo in the early mouse embryo. Nature. 2019 May 22. doi:
    10.1038/s41586-019-1233-0.
  • Cooper JC, Lukacs A, Reich S, Schauer T, Imhof A, Phadnis N. Altered localization of hybrid incompatibility proteins in Drosophila. Mol Biol Evol. 2019 Apr 30. pii: msz105. doi: 10.1093/molbev/msz105
  • Höpfler M, Kern MJ, Straub T, Prytuliak R, Habermann BH, Pfander B, Jentsch S. Slx5/Slx8-dependent ubiquitin hotspots on chromatin contribute to stress tolerance. EMBO J. 2019 Apr 23. pii: e100368. doi: 10.15252/embj.2018100368.
  • Pernice HF, Schieweck R, Jafari M, Straub T, Bilban M, Kiebler MA, Popper B. Altered Glutamate Receptor Ionotropic Delta Subunit 2 Expression in Stau2-Deficient Cerebellar Purkinje Cells in the Adult Brain. Int J Mol Sci. 2019
    Apr 11;20(7). doi: 10.3390/ijms20071797
  • Benitz S, Straub T, Mahajan UM, Mutter J, Czemmel S, Unruh T, Wingerath B, Deubler S, Fahr L, Cheng T, Nahnsen S, Bruns P, Kong B, Raulefs S, Ceyhan GO, Mayerle J, Steiger K, Esposito I, Kleeff J, Michalski CW, Regel I. Ring1b-dependent epigenetic remodelling is an essential prerequisite for pancreatic carcinogenesis. Gut. 2019 Apr 6.
    doi: 10.1136/gutjnl-2018-317208
  • Buschle A, Mrozek-Gorska P, Krebs S, Blum H, Cernilogar FM, Schotta G, Pich D, Straub T, Hammerschmidt W. Epstein-Barr virus inactivates the transcriptome and disrupts the chromatin architecture of its host cell in the first phase of lytic reactivation. bioRxiv. https://doi.org/10.1101/573659

2018

  • Baldi S, Jain DS, Harpprecht L, Zabel A, Scheibe M, Butter F, Straub T, Becker PB. Genome-wide Rules of Nucleosome Phasing in Drosophila. Mol Cell. 2018 Oct 19. pii: S1097-2765(18)30803-7. 
    doi: 10.1016/j.molcel.2018.09.032
  • Diana Pauly, Nicole Schäfer, Felix Grassmann, Anna M Pfaller, Tobias Straub, Bernhard HF Weber, Stefanie M. Hauck, Antje Grosche. Cell type-specific complement expression from healthy and diseased retinae. bioRxiv. https://doi.org/10.1101/413088
  • Angerilli A, Smialowski P, Rupp RA. The Xenopus animal cap transcriptome: building a mucociliary epithelium. The Xenopus animal cap transcriptome: building a mucociliary epithelium. Nucleic Acids Res. 2018 Aug 27. https://doi.org/10.1093/nar/gky771
  • Atkinson SR, Marguerat S, Bitton DA, Rodríguez-López M, Rallis C, Lemay JF, Cotobal C, Malecki M, Smialowski P, Mata J, Korber P, Bachand F, Bähler J. Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast. RNA. 2018 Sep;24(9):1195-1213. https://doi.org/10.1261/rna.065524.118
  • Riedemann T, Straub T, Sutor B. Two types of somatostatin-expressing GABAergic interneurons in the superficial layers of the mouse cingulate cortex. PLoS One. 2018 Jul 12;13(7):e0200567. https://doi.org/10.1371/journal.pone.0200567
  • Salvermoser J, van Blijswijk J, Papaioannou NE, Rambichler S, Pasztoi M, Pakalniškytė D, Rogers NC, Keppler SJ, Straub T, Reis E Sousa C, Schraml BU. Clec9a-Mediated Ablation of Conventional Dendritic Cells Suggests a Lymphoid Path to Generating Dendritic Cells In Vivo. Front Immunol. 2018 Apr 16;9:699. https://doi.org/10.3389/fimmu.2018.00699
  • Alessandro Scacchetti, Laura Brueckner, Dhawal Jain, Tamas Schauer, Xu Zhang, Frank Schnorrer, Bas van Steensel, Tobias Straub, Peter B. Becker. CHRAC/ACF Contribute to the Repressive Ground State of Chromatin. Life Science Alliance. Published 9 February 2018. https://doi.org/10.26508/lsa.201800024 

2017

  • Alessandro Scacchetti, Laura Brueckner, Dhawal Jain, Tamas Schauer, Xu Zhang, Frank Schnorrer, Bas van Steensel, Tobias Straub, Peter B. Becker. CHRAC/ACF Contribute to the Repressive Ground State of Chromatin. bioRxiv. https://doi.org/10.1101/218768
  • Krendl C, Shaposhnikov D, Rishko V, Ori C, Ziegenhain C, Sass S, Simon L, Müller NS, Straub T, Brooks KE, Chavez SL, Enard W, Theis FJ, Drukker M. GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency. Proc Natl Acad Sci U S A. http://doi.org/10.1073/pnas.1708341114
  • Follwaczny P, Schieweck R, Riedemann T, Demleitner A, Straub T, Klemm AH, Bilban M, Sutor B, Popper B, Kiebler MA. Pumilio2 deficient mice show a predisposition for epilepsy.  Dis Model Mech. http://doi.org/10.1242/dmm.029678
  • Pünzeler S, Link S, Wagner G, Keilhauer EC, Kronbeck N, Spitzer RM, Leidescher S, Markaki Y, Mentele E, Regnard C, Schneider K, Takahashi D, Kusakabe M, Vardabasso C, Zink LM, Straub T, Bernstein E, Harata M, Leonhardt H, Mann M, Rupp RA, Hake SB. Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation. EMBO J. http://doi.org/10.15252/embj.201695757
  • Dillinger S, Straub T, Németh A. Nucleolus association of chromosomal domains is largely maintained in cellular senescence despite massive nuclear reorganisation. PLoS One http://doi.org/10.1371/journal.pone.0178821
  • Wagner G, Singhal N, Nicetto D, Straub T, Kremmer E, Rupp RAW. Brg1 chromatin remodeling ATPase balances germ layer patterning by amplifying the transcriptional burst at midblastula transition. PLoS Genet. doi: 10.1371/journal.pgen.1006757
  • Barthels C, Ogrinc A, Steyer V, Meier S, Simon F, Wimmer M, Blutke A, Straub T, Zimber-Strobl U, Lutgens E, Marconi P, Ohnmacht C, Garzetti D, Stecher B, Brocker T. CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis. Nat Commun. http://doi:10.1038/ncomms14715
  • Gerland, T. A., Sun, B., Smialowski, P., Lukacs, A., Thomae, A. W., & Imhof, A. The Drosophila speciation factor HMR localizes to genomic insulator sites. PloS One. http://doi.org/10.1371/journal.pone.0171798

2016

  • Jain, D.S., Baldi, S., Zabel, A., Straub, T., Becker P.B. Genome-wide analysis of phased nucleosomal arrays reveals the functional characteristic of the nucleosome remodeler ACF. bioRxiv. http://dx.doi.org/10.1101/093666
  • Villa R, Schauer T, Smialowski P, Straub T, Becker PB. PionX sites mark the X chromosome for dosage compensation. Nature. http://dx.doi.org/10.1038/nature19338
  • Dillinger S, Straub T, Németh A. Nucleolus association of chromosomal domains is largely maintained in cellular senescence despite massive nuclear reorganisation. bioRxiv. http://dx.doi.org/10.1101/054908
  • Kammerl IE, Dann A, Mossina A, Brech D, Lukas C, Vosyka O, Nathan P, Conlon TM, Wagner DE, Overkleeft HS, Prasse A, Rosas IO, Straub T, Krauss-Etschmann S, Königshoff M, Preissler G, Winter H, Lindner M, Hatz R, Behr J, Heinzelmann K, Yildirim AÖ, Noessner E, Eickelberg O, Meiners S. Impairment of Immunoproteasome Function by Cigarette Smoke and in COPD. American Journal of Respiratory and Critical Care Medicine. http://doi.org/10.1164/rccm.201506-1122OC
  • Peleg S, Feller C, Forne I, Schiller E, Sévin DC, Schauer T, Regnard C, Straub T, Prestel M, Klima C, Schmitt Nogueira M, Becker L, Klopstock T, Sauer U, Becker PB, Imhof A, Ladurner AG. Life span extension by targeting a link between metabolism and histone acetylation in Drosophila. EMBO Reports. http://doi.org/10.15252/embr.201541132
  • Schüller R, Forné I, Straub T, Schreieck A, Texier Y, Shah N, Decker TM, Cramer P, Imhof A, Eick D. Heptad-Specific Phosphorylation of RNA Polymerase II CTD. Molecular Cell. http://doi.org/10.1016/j.molcel.2015.12.003

2015

  • Heiseke AF, Jeuk BH, Markota A, Straub T, Lehr HA, Reindl W, Krug AB. IRAK1 Drives Intestinal Inflammation by Promoting the Generation of Effector Th Cells with Optimal Gut-Homing Capacity. Journal of Immunology (Baltimore, Md. : 1950). http://doi.org/10.4049/jimmunol.1501874
  • Jain D, Baldi S, Zabel A, Straub T, Becker PB. Active promoters give rise to false positive “Phantom Peaks” in ChIP-seq experiments. Nucleic Acids Research. http://doi.org/10.1093/nar/gkv637
  • Pataskar A, Jung J, Smialowski P, Noack F, Calegari F, Straub T, Tiwari VK. NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program. The EMBO Journal. http://doi.org/10.15252/embj.201591206
  • Vardabasso C, Gaspar-Maia A, Hasson D, Pünzeler S, Valle-Garcia D, Straub T, Keilhauer EC, Strub T, Dong J, Panda T, Chung CY, Yao JL, Singh R, Segura MF, Fontanals-Cirera B, Verma A, Mann M, Hernando E, Hake SB, Bernstein E. Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma. Molecular Cell. http://doi.org/10.1016/j.molcel.2015.05.009

2013

  • Nicetto, D., Hahn, M., Jung, J., Schneider, T. D., Straub, T., David, R., et al. (2013). Suv4-20h histone methyltransferases promote neuroectodermal differentiation by silencing the pluripotency-associated oct-25 gene. PLoS Genetics, 9(1), e1003188. http://doi.org/10.1371/journal.pgen.1003188
  • Straub, T., & Becker, P. B. (2013). Comment on “Drosophila Dosage Compensation Involves Enhanced Pol II Recruitment to Male X-Linked Promoters.” Science (New York, NY), 340(6130), 273. http://doi.org/10.1126/science.1231895
  • Taverna, M., Straub, T., Hampel, H., Rujescu, D., & Lichtenthaler, S. F. (2013). A New Sandwich Immunoassay for Detection of the α-Secretase Cleaved, Soluble Amyloid-β Protein Precursor in Cerebrospinal Fluid and Serum. Journal of Alzheimer's Disease : JAD. http://doi.org/10.3233/JAD-130509

2012

  • Eckey, M., Kuphal, S., Straub, T., Rümmele, P., Kremmer, E., Bosserhoff, A. K., & Becker, P. B. (2012). Nucleosome remodeler SNF2L suppresses cell proliferation and migration and attenuates Wnt signaling. Molecular and Cellular Biology. http://doi.org/10.1128/MCB.06619-11
  • Feller, C., Prestel, M., Hartmann, H., Straub, T., Soeding, J., & Becker, P. B. (2012). The MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset. Nucleic Acids Research, 40(4), 1509–1522. http://doi.org/10.1093/nar/gkr869
  • Gilfillan, G. D., Hughes, T., Sheng, Y., Hjorthaug, H. S., Straub, T., Gervin, K., et al. (2012). Limitations and possibilities of low cell number ChIP-seq. BMC Genomics, 13, 645. http://doi.org/10.1186/1471-2164-13-645
  • Straub, T., Zabel, A., Gilfillan, G. D., Feller, C., & Becker, P. B. (2012). Different chromatin interfaces of the Drosophila dosage compensation complex revealed by high-shear ChIP-seq. Genome Research. http://doi.org/10.1101/gr.146407.112
  • Villa, R., Forné, I., Müller, M., Imhof, A., Straub, T., & Becker, P. B. (2012). MSL2 Combines Sensor and Effector Functions in Homeostatic Control of the Drosophila Dosage Compensation Machinery. Molecular Cell. http://doi.org/10.1016/j.molcel.2012.09.012

before 2012

  • Bartkuhn, M., Straub, T., Herold, M., Herrmann, M., Rathke, C., Saumweber, H., et al. (2009). Active promoters and insulators are marked by the centrosomal protein 190. The EMBO Journal, 28(7), 877–888. http://doi.org/10.1038/emboj.2009.34
  • Bonaldi, T., Straub, T., Cox, J., Kumar, C., Becker, P. B., & Mann, M. (2008). Combined use of RNAi and quantitative proteomics to study gene function in Drosophila. Molecular Cell, 31(5), 762–772. http://doi.org/10.1016/j.molcel.2008.07.018
  • Gilfillan, G. D., Straub, T., de Wit, E., Greil, F., Lamm, R., van Steensel, B., & Becker, P. B. (2006). Chromosome-wide gene-specific targeting of the Drosophila dosage compensation complex. Genes & Development, 20(7), 858–870. http://doi.org/10.1101/gad.1399406
  • Lantermann, A. B., Straub, T., Strålfors, A., Yuan, G.-C., Ekwall, K., & Korber, P. (2010). Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae. Nature Structural & Molecular Biology, 17(2), 251–257. http://doi.org/10.1038/nsmb.1741
  • Linder, B., Mentele, E., Mansperger, K., Straub, T., Kremmer, E., & Rupp, R. A. W. (2007). CHD4/Mi-2beta activity is required for the positioning of the mesoderm/neuroectoderm boundary in Xenopus. Genes & Development, 21(8), 973–983. http://doi.org/10.1101/gad.409507
  • Prestel, M., Feller, C., Straub, T., Mitlöhner, H., & Becker, P. B. (2010). The activation potential of MOF is constrained for dosage compensation. Molecular Cell, 38(6), 815–826. http://doi.org/10.1016/j.molcel.2010.05.022
  • Regnard, C., Straub, T., Mitterweger, A., Dahlsveen, I. K., Fabian, V., & Becker, P. B. (2011). Global analysis of the relationship between JIL-1 kinase and transcription. PLoS Genetics, 7(3), e1001327. http://doi.org/10.1371/journal.pgen.1001327
  • Straub, T., Gilfillan, G. D., Maier, V. K., & Becker, P. B. (2005a). The Drosophila MSL complex activates the transcription of target genes. Genes & Development, 19(19), 2284–2288. http://doi.org/10.1101/gad.1343105
  • Straub, T., Grimaud, C., Gilfillan, G. D., Mitterweger, A., & Becker, P. B. (2008). The chromosomal high-affinity binding sites for the Drosophila dosage compensation complex. PLoS Genetics, 4(12), e1000302. http://doi.org/10.1371/journal.pgen.1000302
  • Wiedemann, S. M., Mildner, S. N., Boenisch, C., Israel, L., Maiser, A., Matheisl, S., et al. (2010). Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y. The Journal of Cell Biology, 190(5), 777–791. http://doi.org/10.1083/jcb.201002043